Reedle Shot uses the star ingredient CICA REEDLE (fine natural micro-needles obtained from Silica (Hydrolysed Sponge) containing Centella Asiatica Extract). VT Reedle Shot 100 has the mildest form of tingling sensation and is suited for daily use when using it alone. To be used after cleansing the face before toners. This helps amp up the benefits of any following skincare and helps with texture improvement over time. The tingling sensation is very mild for me. Best to pair this with 300 or 700 Reedle Shot for maximum benefits.